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Residual plots were constructed to check appropriate model fit; in addition, continuous covariates were considered as categorical ones with varying categories to assess the sensitivity of test statistics. Individuals from selected census blocks were chosen to achieve the goal of approximately equal numbers of black, white, and Hispanic men and women in four age categories: Association of prostate cancer risk and aggressiveness to androgen pathway genes: Prostate-specific antigen and androgens in African-American and white normal subjects and prostate cancer patients. Because differences in body composition, particularly body mass index, could affect SHBG levels and thereby influence total testosterone levels, we also measured SHBG levels Racial difference in circulating sex hormone-binding globulin levels in prepubertal boys. Hormone variables were log-base 10 transformed because their distributions were skewed.

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All participants provided written, informed consent. Most studies 1 , 2 , 5 , 6 — 8 , with some exceptions 3 , 4 , included small numbers of blacks, and none had significant representation of Hispanics.

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Of men recruited, provided blood samples black, Hispanic, white. Subjects were then asked: Sign In or Create an Account. Prostate-specific antigen and androgens in African-American and white normal subjects and prostate cancer patients. To be representative of the city of Boston, observations were weighted inversely proportional to their probability of selection into the study Further research is needed to determine whether higher DHT levels and DHT to testosterone ratios in black men are due to polymorphisms in SRD5A2 gene and whether these small differences can explain the racial disparities in prostate cancer incidence and prevalence rates.

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